Homocysteine, vitamin B12, and folate circulating levels in women with and without polycystic ovary syndrome: A systematic review and meta-analysis
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View abstract on PubMed
Summary
This summary is machine-generated.Polycystic ovary syndrome (PCOS) is linked to higher homocysteine levels, but not vitamin B12 or folate levels, according to a systematic review. This meta-analysis clarifies nutrient associations in PCOS patients.
Area Of Science
- Endocrinology
- Nutritional Science
- Reproductive Medicine
Background
- Polycystic ovary syndrome (PCOS) is a common endocrine disorder with complex metabolic implications.
- Previous research on the association between homocysteine, vitamin B12, and folate levels in PCOS has yielded conflicting results.
- Understanding these nutrient associations is crucial for managing PCOS-related health risks.
Purpose Of The Study
- To systematically review and meta-analyze existing evidence on homocysteine, vitamin B12, and folate levels in women with and without PCOS.
- To provide a comprehensive overview of the current scientific literature on this topic.
Main Methods
- Systematic literature search across major databases (PubMed, Ovid/Medline, Scopus, Embase, Web of Science) without language restrictions.
- Quality assessment of included studies using the Newcastle-Ottawa Scale.
- Quantitative synthesis of data using standardized mean differences (SMDs) with 95% confidence intervals (CI) via the DerSimonian and Laird method.
Main Results
- A total of 75 studies were included in the meta-analysis.
- Women with PCOS showed significantly higher circulating homocysteine levels compared to controls (SMD: 0.82; 95% CI: 0.62-1.02).
- No significant differences were found in circulating vitamin B12 (SMD: -0.11; 95% CI: -0.25 to 0.03) or folate levels (SMD: -0.2; 95% CI: -0.68 to 0.27) between PCOS patients and controls.
Conclusions
- Patients with PCOS exhibit significantly elevated homocysteine levels.
- Circulating vitamin B12 and folate levels do not significantly differ between women with and without PCOS.
- These findings highlight homocysteine as a potential biomarker in PCOS, while B12 and folate may not be directly associated.
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