Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

3.9K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.9K
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

75
Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular...
75
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

28
PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
28
Diabetic Retinopathy01:27

Diabetic Retinopathy

55
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
55
Diabetic Nephropathy01:28

Diabetic Nephropathy

32
Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration...
32
Diabetic Neuropathy01:22

Diabetic Neuropathy

59
DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
59

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Large Separable Kernel Attention-Driven Multidimensional Feature Cross-Level Fusion Classification Network of Knee Cartilage Injury: Algorithm Development and Validation.

JMIR medical informatics·2025
Same author

Relationship between occupational stress and coping strategy among operating theatre nurses in China: a questionnaire survey.

Journal of nursing management·2013
Same author

Increased asthma risk and asthma-related health care complications associated with childhood obesity.

American journal of epidemiology·2013
Same author

Anomalous N-glycan structures with an internal fucose branched to GlcA and GlcN residues isolated from a mollusk shell-forming fluid.

Journal of proteome research·2013
Same author

[Inhibitory effect of arsenic trioxide combined with cisplatin on human nasopharyngeal carcinoma xenograft and DAPK in nude mice].

Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery·2013
Same author

Interaction between occupational stress and GR gene polymorphisms on essential hypertension among railway workers.

Journal of occupational health·2013

Related Experiment Video

Updated: May 4, 2026

Retinal Pathophysiological Evaluation in a Rat Model
09:11

Retinal Pathophysiological Evaluation in a Rat Model

Published on: May 6, 2022

4.5K

Classification of diabetic retinopathy algorithm based on a novel dual-path multi-module model.

Lirong Zhang1, Jialin Gang2, Jiangbo Liu2

  • 1The School of Digital Art and Design, Dalian Neusoft University of Information, Dalian, Liaoning, China. zhanglirong1997@163.com.

Medical & Biological Engineering & Computing
|September 25, 2024
PubMed
Summary
This summary is machine-generated.

A new algorithm accurately classifies diabetic retinopathy (DR) stages using a dual-path multi-module network. This advancement aids early diagnosis and treatment, crucial for preventing vision loss in diabetic patients.

Keywords:
Deep learningDiabetic retinopathy classificationDual-path multi-module model

More Related Videos

Author Spotlight: Unraveling the Pathogenesis of Age-Related Macular Degeneration and Discovering Potential Therapies
06:16

Author Spotlight: Unraveling the Pathogenesis of Age-Related Macular Degeneration and Discovering Potential Therapies

Published on: July 28, 2023

2.4K
Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression
04:36

Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression

Published on: January 12, 2024

1.0K

Related Experiment Videos

Last Updated: May 4, 2026

Retinal Pathophysiological Evaluation in a Rat Model
09:11

Retinal Pathophysiological Evaluation in a Rat Model

Published on: May 6, 2022

4.5K
Author Spotlight: Unraveling the Pathogenesis of Age-Related Macular Degeneration and Discovering Potential Therapies
06:16

Author Spotlight: Unraveling the Pathogenesis of Age-Related Macular Degeneration and Discovering Potential Therapies

Published on: July 28, 2023

2.4K
Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression
04:36

Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression

Published on: January 12, 2024

1.0K

Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Artificial Intelligence

Background:

  • Diabetic retinopathy (DR) is a diabetes complication affecting retinal blood vessels.
  • Progressive DR can lead to significant vision impairment and blindness.
  • Early detection and intervention are critical for managing DR and preserving sight.

Purpose of the Study:

  • To introduce a novel dual-path multi-module network algorithm for accurate diabetic retinopathy classification.
  • To enhance early diagnosis and timely intervention for diabetic retinopathy.

Main Methods:

  • Utilized color correcting and multi-scale fusion for retinal lesion feature enhancement.
  • Employed a multi-path multiplexing structure with varying convolutional kernel sizes for local data optimization.
  • Integrated a multi-feature fusion module to boost classification model accuracy.

Main Results:

  • Achieved high classification accuracies of 98.9%, 99.3%, and 98.3% on public and hospital datasets.
  • Demonstrated the algorithm's effectiveness in automatic diabetic retinopathy diagnosis.
  • Validated the algorithm's practicality and advancement in the field.

Conclusions:

  • The proposed algorithm shows significant promise for automatic DR diagnosis.
  • This technology offers strong potential for clinical application in early DR screening and treatment.
  • The findings support improved patient outcomes by facilitating timely medical intervention.