Related Experiment Video
Updated: Jun 12, 2025
09:38
Direct Reprogramming of Mouse Fibroblasts into Melanocytes
Published on: August 27, 2021
2.0K
Post-translational modification in the pathogenesis of vitiligo.
Lu Lu1, Huimin He1, Jindi Feng1
1Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, China.
Immunologic Research
|September 25, 2024
Summary
This review explores how protein post-translational modifications influence vitiligo, a skin pigmentation disorder. Understanding these changes offers potential for new vitiligo treatments targeting immune response and melanocyte survival.
Area of Science:
- Dermatology
- Immunology
- Molecular Biology
Background:
- Vitiligo is a chronic skin condition causing pigment loss.
- Its exact causes are complex and not fully understood.
- Protein post-translational modifications (PTMs) are crucial in skin inflammation but understudied in vitiligo.
Purpose of the Study:
- To review the role of PTMs in vitiligo pathogenesis.
- To examine PTMs' impact on immune signaling and melanocyte survival.
- To discuss current and potential therapies targeting these pathways.
Main Methods:
- Literature review of studies on PTMs and vitiligo.
- Analysis of PTMs' effects on cellular signaling pathways.
- Synthesis of information on therapeutic strategies.
Main Results:
- PTMs significantly influence vitiligo development.
- Specific PTMs affect immune cell function and melanocyte viability.
- Targeting PTM pathways shows therapeutic promise.
Conclusions:
- PTMs are key players in vitiligo pathogenesis.
- Further research into PTMs can lead to novel vitiligo treatments.
- Targeted therapies offer hope for improved vitiligo management.
Related Concept Videos
02:04Covalently Linked Protein Regulators
6.8K
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
These groups modify specific amino acids in a protein....
6.8K
01:22Photoreceptors and Visual Pathways
5.9K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
5.9K
01:23Skin Diseases and Disorders
3.7K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
3.7K
01:33Pleiotropy
40.3K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
40.3K
01:16TGF - β Signaling Pathway
7.3K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
7.3K
01:14Changes in Skin Color: Clinical Perspectives
1.8K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
1.8K