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Updated: Jun 12, 2025

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
A novel approach for heart disease prediction using hybridized AITH2O algorithm and SANFIS classifier
Jayachitra Sekar1, Prasanth Aruchamy2
1Department of Electronics and Communication Engineering, PSNA College of Engineering and Technology, Dindigul, India.
Insights
This study introduces a novel hybrid optimization algorithm (AITH²O) to enhance heart disease prediction accuracy. The new method significantly improves diagnostic performance in smart healthcare applications.
Area of Science:
- Cardiology
- Artificial Intelligence
- Machine Learning
Background:
- Heart disease poses a significant global health threat, leading to high mortality and morbidity.
- Accurate early prediction of heart disease is crucial for effective patient treatment and medical recommendations.
- Existing machine learning models face challenges with computational complexity and overfitting, limiting diagnostic accuracy.
Purpose of the Study:
- To develop a novel hybrid optimization algorithm for improved heart disease classification accuracy.
- To optimize computation time in smart healthcare applications for heart disease prediction.
- To address the limitations of existing machine learning classifiers in terms of accuracy and efficiency.
Main Methods:
- Feature selection using the hybrid Arithmetic Optimization and Inter-Twinned Mutation-Based Harris Hawk Optimization (AITH²O) algorithm.
- Parameter tuning of the Stabilized Adaptive Neuro-Fuzzy Inference System (SANFIS) classifier with the AITH²O algorithm.
- Validation using the Cleveland heart disease dataset and simulation in MATLAB 2020a.
Main Results:
- The proposed hybrid AITH²O algorithm demonstrates strong exploration and exploitation capabilities with faster convergence.
- The hybrid SANFIS classifier achieved a superior accuracy of 99.28% for heart disease prediction.
- A true positive rate of 99.46% was attained, outperforming existing state-of-the-art techniques.
Conclusions:
- The developed hybrid optimization algorithm (AITH²O) effectively enhances the accuracy and efficiency of heart disease prediction.
- The Stabilized Adaptive Neuro-Fuzzy Inference System (SANFIS) classifier, optimized by AITH²O, offers a promising solution for smart healthcare diagnostics.
- This approach provides a robust and accurate method for early detection and management of heart disease.
Abstract:
In today's world, heart disease threatens human life owing to higher mortality and morbidity across the globe. The earlier prediction of heart disease engenders interoperability for the treatment of patients and offers better diagnostic recommendations from medical professionals. However, the existing machine learning classifiers suffer from computational complexity and overfitting problems, which reduces the classification accuracy of the diagnostic system. To address these constraints, this work proposes a new hybrid optimization algorithm to improve the classification accuracy and optimize computation time in smart healthcare applications. Primarily, the optimal features are selected through the hybrid Arithmetic Optimization and Inter-Twinned Mutation-Based Harris Hawk Optimization (AITH2O) algorithm. The proposed hybrid AITH2O algorithm entails advantages of both exploration and exploitation abilities and acquires faster convergence. It is further employed to tune the parameters of the Stabilized Adaptive Neuro-Fuzzy Inference System (SANFIS) classifier for predicting heart disease accurately. The Cleveland heart disease dataset is utilized to validate the efficacy of the proposed algorithm. The simulation is carried out using MATLAB 2020a environment. The simulation results show that the proposed hybrid SANFIS classifier attains a superior accuracy of 99.28% and true positive rate of 99.46% compared to existing state-of-the-art techniques.
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