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Blood Flow

Blood Flow

Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow.

Laminar and Turbulent Flow

Laminar and Turbulent Flow

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Related Experiment Video

Updated: Jul 21, 2026

Image-guided, Laser-based Fabrication of Vascular-derived Microfluidic Networks

Image-guided, Laser-based Fabrication of Vascular-derived Microfluidic Networks

Published on: January 3, 2017

Modeling Hemodynamics in Three-Dimensional, Biomimetic, Branched, Microfluidic, Vascular Networks.

Rahul Ramanathan¹, Andy Borum^2,3, David M Rooney²

¹Bioengineering Program, DeMatteis School of Engineering and Applied Science, Hofstra University, Hempstead, New York, USA.

Microcirculation (New York, N.Y. : 1994)

|September 25, 2024

Summary

A new mathematical model predicts blood flow in capillary beds by analyzing vessel structure. This tool aids research in neovascularization and tissue engineering for regenerative medicine.

Keywords:

capillary network computational modeling hemodynamics retinal microcirculation vascular biology

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Perfusable Vascular Network with a Tissue Model in a Microfluidic Device

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Microfluidic Model to Mimic Initial Event of Neovascularization

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Published on: April 10, 2021

Related Experiment Videos

Last Updated: Jul 21, 2026

Image-guided, Laser-based Fabrication of Vascular-derived Microfluidic Networks

Image-guided, Laser-based Fabrication of Vascular-derived Microfluidic Networks

Published on: January 3, 2017

Perfusable Vascular Network with a Tissue Model in a Microfluidic Device

Perfusable Vascular Network with a Tissue Model in a Microfluidic Device

Published on: April 4, 2018

Microfluidic Model to Mimic Initial Event of Neovascularization

Microfluidic Model to Mimic Initial Event of Neovascularization

Published on: April 10, 2021

Area of Science:

Biomedical Engineering
Physiology
Microfluidics

Background:

Neovascularization is crucial in physiological and disease processes.
Vascular microfluidic platforms recreate in vitro environments for neovascularization.
Biomechanical properties and fluid dynamics in engineered tissues mimic organ systems for personalized medicine.

Purpose of the Study:

To present a mathematical model for predicting hemodynamic parameters in capillary beds.
To demonstrate the model's application in microfluidic systems.

Main Methods:

Developing a mathematical model based on branching patterns and vessel morphology.
Utilizing fluid hemodynamics to study flow patterns and mimic physiological processes.
Applying shear stress to encourage endothelial cell proliferation and differentiation.

Main Results:

The model predicts hemodynamic parameters in capillary beds using branching patterns and vessel morphology.
A retinal capillary bed was used as a case study to validate the model's applicability.
Demonstrated the framework's utility for determining hemodynamic parameters in microfluidic systems.

Conclusions:

The developed mathematical model can predict hemodynamic parameters in capillary beds.
This tool can be adapted to support research in neovascularization.
The model facilitates the creation of systems mimicking physiological pathways for regenerative medicine.