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Updated: Jun 12, 2025
Multiplexing Focused Ultrasound Stimulation with Fluorescence Microscopy
Published on: January 7, 2019
The Use of Focused Ultrasound to Enhance Liquid Biopsy
Ying Meng1, Christopher B Pople2, Nir Lipsman1
1Division of Neurosurgery, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario, Canada; Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, University of Toronto Canada, 2075 Bayview Avenue, Toronto, Ontario, Canada.
Abstract:
Breakthroughs in medical imaging and ultrasound transducer design have led to feasible application of focused ultrasound (FUS) to intracranial pathologies. Currently, one of the most active fields in FUS has been the temporary disruption the blood-brain barrier. In addition to enhancing drug delivery to the brain, FUS blood-brain barrier disruption may allow liberation of biomarkers from the brain, thus facilitating ease of detection and adding the element of spatial specificity to an otherwise nonspecific test. This study reviews the current evidence to support FUS liquid biopsy and the challenges of advancing this field.
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