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Emerging Monkeypox Virus Sublineage C.1 Causing Community Transmission, Vietnam, 2023
Emerging Infectious Diseases
|September 25, 2024
Summary
A monkeypox virus (mpox) cluster in Vietnam, driven by sublineage C.1, involved two importations and a novel mutation. Three deaths occurred, all in patients with advanced HIV co-infection, highlighting the need for monitoring viral evolution.
Area of Science:
- Virology
- Epidemiology
- Public Health
Background:
- Mpox (monkeypox virus) outbreaks have emerged globally.
- Understanding viral lineages and transmission dynamics is crucial for public health responses.
Purpose of the Study:
- To investigate a community cluster of 25 mpox cases in Vietnam.
- To identify the causative mpox virus sublineage and its origins.
- To analyze viral genetic mutations and their association with clinical outcomes.
Main Methods:
- Phylogenetic analysis of mpox virus genomes.
- Epidemiological investigation of case clusters.
- Clinical data review of affected patients.
Main Results:
- A cluster of 25 mpox cases was linked to emerging sublineage C.1, imported via two independent events.
- A major cluster exhibited a novel APOBEC3-like mutation.
- Three fatalities were recorded, all in patients with advanced HIV co-infection.
Conclusions:
- Emerging mpox sublineage C.1 poses a threat, as evidenced by the Vietnam cluster.
- The novel APOBEC3-like mutation warrants further investigation.
- Advanced HIV co-infection is a significant risk factor for severe mpox outcomes, necessitating close monitoring of viral evolution.
Keywords:
HIV co-infectionVietnamgenetic changesmonkeypox virusmpoxsexually transmitted infectionssublinear C1virusesMore Related Videos
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