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Updated: Jun 12, 2025

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects
Published on: May 4, 2021
Mitigating the systemic loss of nitrous oxide: a narrative review and data-driven practice analysis
Brian B Chesebro1, Seema Gandhi2
1Center for Environmental Stewardship, Providence Health & Services, Renton, WA, USA; Oregon Anesthesiology Group PC, Portland, OR, USA.
Clinicians must address nitrous oxide (N2O) emissions from central supply systems, a major source of greenhouse gases in healthcare. Switching to portable systems drastically cuts N2O use, reducing environmental impact.
Area of Science:
- Environmental Science
- Healthcare Sustainability
- Anesthesiology
Background:
- Climate change poses significant health risks, necessitating environmental responsibility in clinical practices.
- Inhaled anesthetics like nitrous oxide (N2O) are potent greenhouse gases with long atmospheric lifetimes and high global warming potential.
- Central N2O supply systems in healthcare facilities are a major, often overlooked, source of unnecessary greenhouse gas emissions.
Purpose of the Study:
- To review the environmental impact of N2O in healthcare settings.
- To present N2O utilization data from 47 US hospitals.
- To provide guidance for clinicians to mitigate N2O emissions.
Main Methods:
- Analysis of N2O utilization data from two large US healthcare systems.
- Review of existing literature on N2O environmental impact and mitigation strategies.
- Case study illustrating the impact of transitioning from central to portable N2O supply systems.
Main Results:
- Significant non-clinical N2O losses (47.2-99.8%) were identified in US healthcare systems, consistent with UK and Australian findings.
- Transitioning from central to portable N2O supply systems reduced N2O consumption by 97.6% in one quaternary medical center.
- This mitigation strategy has been successfully adopted by over 25 hospitals.
Conclusions:
- Central N2O supply systems represent a substantial and under-recognized source of greenhouse gas emissions in healthcare.
- Switching to portable N2O supply systems is a highly effective strategy for reducing N2O consumption and environmental impact.
- Clinicians are empowered to lead facility-level initiatives for decarbonization and improved environmental stewardship in healthcare.
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