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Updated: Jun 12, 2025

A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes
Published on: February 5, 2018
APOE4 affects neutrophil-microglia crosstalk in Alzheimer's disease
Eleonora Terrabuio1, Gabriela Constantin2
1Department of Medicine, University of Verona, Strada le Grazie 8, 37134 Verona, Italy.
Abstract:
Circulating immune cells contribute to the pathogenesis of Alzheimer's disease (AD), but their role is poorly understood. Rosenzweig et al. recently identified a subset of interleukin (IL)-17+ neutrophils that inhibit neuroprotective microglia in female APOE4 carriers. Blockade of IL-17 signaling or APOE4 deletion in neutrophils restored microglial responses and reduced murine amyloid pathology.
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