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Transferrin receptor targeting chimeras for membrane protein degradation

Dingpeng Zhang1,2, Jhoely Duque-Jimenez1, Francesco Facchinetti3,4,5

  • 1Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.

Nature
|September 25, 2024
PubMed
Summary

Researchers developed Transferrin Receptor Targeting Chimeras (TransTACs), a new antibody therapy. TransTACs degrade target membrane proteins in cancer cells by hijacking iron uptake pathways for targeted cancer treatment.

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