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Related Experiment Videos

Thyroxine administration during radiation therapy to the neck does not prevent subsequent thyroid dysfunction.

J P Bantle, C K Lee, S H Levitt

    International Journal of Radiation Oncology, Biology, Physics
    |November 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

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    Administering oral L-thyroxine to suppress thyroid-stimulating hormone (TSH) during neck radiation therapy did not prevent subsequent thyroid dysfunction in lymphoma patients. Thyroid issues still developed in both treated and untreated groups post-treatment.

    Area of Science:

    • Endocrinology
    • Oncology
    • Radiation Therapy

    Background:

    • Neck irradiation for lymphomas can cause hypothyroidism.
    • Thyroid dysfunction poses a significant long-term risk for cancer survivors.

    Purpose of the Study:

    • To investigate if suppressing serum thyroid-stimulating hormone (TSH) with L-thyroxine during neck radiation therapy reduces subsequent hypothyroidism.
    • To evaluate the long-term thyroid function in patients receiving radiation therapy for lymphomas.

    Main Methods:

    • Oral L-thyroxine was given to 20 patients to suppress serum TSH during radiation therapy for lymphomas.
    • A control group of 20 similar patients did not receive L-thyroxine during radiation.
    • Thyroid function was monitored post-radiation therapy.

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    Main Results:

    • After a mean follow-up of 33 months, 35% of the L-thyroxine group developed elevated TSH.
    • In the control group, 25% developed elevated TSH after a mean follow-up of 19 months.
    • No significant difference in the incidence of hypothyroidism was observed between the groups.

    Conclusions:

    • Suppression of serum TSH during neck irradiation does not prevent the development of subsequent thyroid dysfunction.
    • Prophylactic L-thyroxine during radiation therapy is not effective in preventing hypothyroidism in lymphoma patients.