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Updated: May 2, 2026

Identification of Rare Bacterial Pathogens by 16S rRNA Gene Sequencing and MALDI-TOF MS
Published on: July 11, 2016
Aldgamycins Q1 and Q2, two novel 16-membered macrolides from the rare actinomycete Saccharothrix sp. 16Sb2-4
Keke Luo1, Qin Yang1, Yuyu Liu1
1Department of Microbial Chemistry, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, 100050, Beijing, China.
Abstract:
Two novel 16-membered macrolides, named aldgamycin Q1 (1) and Q2 (2), were isolated from the culture broth of the rare actinomycete Saccharothrix sp. 16Sb2-4. The structures of 1 and 2 were elucidated as new aldgamycin analogs with a demethylated mycinose residue by spectroscopic analyses and comparison with data of aldgamycin K. Compounds 1 and 2 showed moderate to weak antibacterial activities against Enterococcus faecalis, Bacillus subtilis, Staphylococcus aureus and Acinetobacter baumannii, with MIC values ranging from 16 to 64 μg mL-1.
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