Electrochemical Halogenation of Naphthoquinones: A Modular and Sustainable Strategy Towards Trypanocidal Compounds
Eduardo F S Guimarães1, Gabriela A P Graça1, Emilay B T Diogo1
1Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil.
Abstract:
An eco-friendly electrochemical halogenation of 2-amino-1,4-naphthoquinones has been developed. The new mild and energy efficient methodology comprises sustainable features like oxidant free and double role of the halogen source as electrolyte, originating twenty-six amino-halogenated naphthoquinoidal derivatives in good yields under mild conditions. This novel methodology permitted access to new potent trypanocidal prototypes, where six compounds were more active than benznidazole, the current market drug used in the treatment of Chagas Disease.
More Related Videos
Related Concept Videos
Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene
Oxidation of Phenols to Quinones
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...
Reactions at the Benzylic Position: Halogenation
Electrophilic Aromatic Substitution: Chlorination and Bromination of Benzene
ortho–para-Directing Deactivators: Halogens
Nucleophilic Aromatic Substitution: Elimination–Addition


