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Nanna Reiter1,2, Kristian Linnet3, Natasja Østermark Andersen4

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Ugeskrift for Laeger
|September 26, 2024
PubMed
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Semi-synthetic cannabinoids like hexahydrocannabinol (HHC) and hexahydrocannabiphorol (HHC-P) pose risks. A case report details severe adverse effects in a young man after consuming HHC and HHC-P, highlighting potential dangers of these unregulated substances.

Area of Science:

  • Pharmacology
  • Toxicology
  • Emergency Medicine

Background:

  • Semi-synthetic cannabinoids are increasingly found in illicit markets, designed to replicate the effects of tetrahydrocannabinol (THC).
  • These novel psychoactive substances pose unknown risks due to unregulated production and variable potency.
  • Limited clinical data exists regarding the acute toxicity of specific semi-synthetic cannabinoids such as HHC and HHC-P.

Observation:

  • A case report details a 19-year-old male hospitalized following the ingestion of food containing hexahydrocannabinol (HHC) and hexahydrocannabiphorol (HHC-P).
  • The patient presented with severe sedation, hypotension, and abnormal heart rhythms (tachycardia and bradycardia).

Findings:

  • Blood analysis confirmed the presence of HHC, HHC-P, and their metabolites.

Related Experiment Videos

  • The identified semi-synthetic cannabinoids were responsible for the observed severe and prolonged clinical symptoms.
  • Implications:

    • This case highlights the potential dangers associated with consuming unregulated semi-synthetic cannabinoids.
    • Illicit product potency can vary significantly, posing risks of acute toxicity and requiring prompt medical intervention.