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Trace Elements in Medicinal Metallomics.
Marina Orlova1,2, Stepan Kalmykov1, Tatiana Trofimova1
1Department of Chemistry, Lomonosov Moscow State University, Moscow, Leninskie Gory, 1, bld. 3, Russian Federation.
Mini Reviews in Medicinal Chemistry
|September 26, 2024
Summary
Trace elements like copper (Cu), manganese (Mn), zinc (Zn), and selenium (Se) are crucial for regulating oxidative stress and related diseases. Understanding their interactions is key for molecular pharmacology and developing new therapeutic strategies.
Area of Science:
- Biochemistry
- Molecular Pharmacology
- Nutritional Science
Background:
- Oxidative stress is implicated in numerous diseases.
- Trace elements play vital roles in biological systems.
- Interactions between microelements are complex and significant.
Purpose of the Study:
- To review the effects of trace elements (Cu, Mn, Zn, Se) on oxidative stress.
- To explore the synergism and competition among microelements.
- To identify potential research directions in molecular pharmacology.
Main Methods:
- Analytical mini-review of existing literature.
- Focus on molecular mechanisms of trace element action.
- Discussion of enzyme-metal interactions.
Main Results:
- Trace elements significantly influence oxidative stress regulation.
- Synergistic and competitive interactions between microelements impact biological effects.
- Metal-coordinating sites on enzymes are pharmacologically relevant targets.
Conclusions:
- Trace elements are critical modulators of oxidative stress and associated pathologies.
- Further research into microelement interactions can advance molecular pharmacology.
- Enzyme active sites involving metals offer therapeutic intervention points.
Keywords:
Enzymatic pharmacophoresdrug targetsmedicinal bio-organic chemistrymetal-dependent enzymesmetallomicstrace elements.
