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Nebuliser therapy in critical care: The past, present and future
Andrew Arnott1, Malcolm Watson1, Malcolm Sim1
1Queen Elizabeth University Hospital, Glasgow, UK.
Journal of the Intensive Care Society
|September 26, 2024
Summary
Vibrating mesh nebulisers (VMN) offer improved drug delivery for critical illnesses compared to older jet (JN) and ultrasonic (USN) devices. This review covers nebuliser evolution, science, and critical care applications.
Area of Science:
- Pulmonary Medicine
- Biomedical Engineering
- Pharmacology
Background:
- Nebulisers convert liquids into inhalable aerosols for drug delivery.
- Pulmonary drug absorption offers efficient local and systemic treatment, especially in critical care.
- Conventional jet (JN) and ultrasonic nebulisers (USN) have limitations in efficiency and particle size.
Purpose of the Study:
- To review the historical development of nebuliser technology.
- To explain the basic science of nebulisation and pulmonary drug delivery.
- To discuss the current applications of nebulised therapies in critical care settings.
Main Methods:
- Literature review of nebuliser technology evolution.
- Analysis of the scientific principles behind nebulisation and aerosol deposition.
- Examination of clinical data on nebulised therapies in critical illness.
Main Results:
- Vibrating mesh nebulisers (VMN) represent a significant advancement over JN and USN.
- VMN technology enhances aerosol generation efficiency and therapeutic potential.
- Nebulised therapies are crucial for managing critical illnesses.
Conclusions:
- VMN have revolutionized nebuliser therapy, offering superior drug delivery.
- Understanding nebuliser science is key to optimizing critical care treatments.
- This review provides a comprehensive overview of nebulisers in critical care.
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