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Immunodeficiency Diseases

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...

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Related Experiment Video

Updated: Jun 12, 2025

Isolation of Brain-infiltrating Leukocytes

Isolation of Brain-infiltrating Leukocytes

Published on: June 13, 2011

Granulomatous Brain Involvement in Common Variable Immunodeficiency: A Case Report.

Maria Rocha¹, Rita Gouveia¹, Ana Neves¹

¹Internal Medicine, Centro Hospitalar Universitário de São João, Porto, PRT.

|September 26, 2024

Summary

Common variable immunodeficiency (CVID) can cause rare brain lesions, even without typical infections. Early diagnosis and treatment with immunoglobulin therapy improved patient outcomes.

Keywords:

autoimmunity case report common variable immunodeficiency granulomatous-lymphocytic interstitial disease infiltrative brain lesions

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Last Updated: Jun 12, 2025

Isolation of Brain-infiltrating Leukocytes

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Published on: June 13, 2011

Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis

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Published on: November 17, 2020

Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells

Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells

Published on: May 19, 2020

Area of Science:

Immunology
Neurology

Background:

Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by impaired B cell differentiation and defective immunoglobulin production.
CVID often presents with recurrent infections, autoimmune diseases, and inflammatory disorders, potentially delaying diagnosis.

Observation:

A woman in her 30s with a history of Evans syndrome and lymphocytic alveolitis presented with persistent headache and multiple infiltrative brain lesions on imaging.
The patient lacked typical recurrent infections but had a history of autoimmune manifestations and immunoglobulin deficiencies.

Findings:

The clinical presentation and history led to a diagnosis of CVID without requiring a brain biopsy.
Treatment with intravenous immunoglobulin and immunosuppressive therapy resulted in significant clinical improvement and resolution of brain lesions.

Implications:

This case underscores the importance of considering CVID in patients with autoimmune manifestations, even in the absence of recurrent infections.
Prompt immunoglobulin replacement and immunosuppression are effective in managing severe CVID presentations, including rare neurological involvement.