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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

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As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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  9. Predictive And Prognostic Markers
  11. Prognostic Signature And Immune Landscape Of 5-methylcytosine-related Long Non-coding Rnas In Gastric Cancer.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Prognostic Signature And Immune Landscape Of 5-methylcytosine-related Long Non-coding Rnas In Gastric Cancer.

Related Experiment Video

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
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Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

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Prognostic signature and immune landscape of 5-methylcytosine-related long non-coding RNAs in gastric cancer.

Qingyu Song1, Jingyu Wu2, Hao Wan3

  • 1Department of General Surgery, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Heliyon
|September 26, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

This study developed a 5-methylcytosine-related long non-coding RNA prognostic signature (m5C-LPS) for gastric cancer (GC). The m5C-LPS accurately predicts patient survival and identifies potential therapeutic targets for GC.

Keywords:
Gastric cancerNomogramSignatureThe tumor immune microenvironment

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MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening
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Area of Science:

  • Oncology
  • Molecular Biology
  • Bioinformatics

Background:

  • Long non-coding RNAs (lncRNAs) show prognostic value in cancer.
  • 5-methylcytosine-related lncRNAs (m5C-lncRNAs) role in gastric cancer (GC) is understudied.
  • Need for novel prognostic markers in GC.

Purpose of the Study:

  • To establish a m5C-lncRNAs prognostic signature (m5C-LPS) for GC.
  • To explore the potential of m5C-LPS in guiding clinical practice for GC.
  • To investigate the relationship between m5C-LPS, tumor microenvironment, and drug sensitivity.

Main Methods:

  • Utilized TCGA data for RNA-sequence and clinicopathological information.
  • Constructed m5C-LPS using univariate and Lasso Cox regression.
  • Validated prognostic value via qRT-PCR, GSEA, CIBERSORT, ESTIMATE, pRRophetic, and TIDE algorithms.
m5C-lncRNAs

Main Results:

  • Identified 280 m5C-lncRNAs, with 11 selected for the prognostic signature.
  • Confirmed expression of 11 m5C-lncRNAs in GC cell lines.
  • Developed a nomogram for precise clinical decision-making; distinct immune and drug sensitivity profiles observed between risk groups.

Conclusions:

  • The m5C-LPS is a valuable tool for predicting GC patient survival.
  • The signature offers novel therapeutic targets for GC.
  • m5C-LPS provides insights for future clinical decisions in GC management.