Association between haptoglobin polymorphism and coronary artery disease: a meta-analysis
Jiao Wang1, Xiaokai Zhou1, Yue Su1
1Department of Cardiology, The Quzhou Affiliated Hospital of Wenzhou Medical University (Quzhou People's Hospital), Quzhou, Zhejiang, China.
Frontiers in Genetics
|September 26, 2024
Summary
Haptoglobin polymorphism is linked to a reduced risk of coronary artery disease (CAD). This association is particularly significant in Asian populations, suggesting a protective role.
Area of Science:
- Genetics
- Cardiovascular Medicine
- Molecular Biology
Background:
- The relationship between haptoglobin rs72294371 polymorphism and coronary artery disease (CAD) risk has been previously investigated with conflicting outcomes.
- Existing research presents uncertainty regarding the specific impact of haptoglobin gene variations on CAD susceptibility.
Purpose of the Study:
- To systematically review and analyze existing literature on the association between haptoglobin polymorphism and coronary artery disease (CAD).
- To clarify the controversial findings regarding haptoglobin gene variants and their role in CAD risk.
Main Methods:
- A comprehensive literature search was conducted across major databases including PubMed, Embase, Web of Science, Cochrane Library, and Wanfang up to April 2024.
- A meta-analysis was performed using pooled odds ratios (OR) and 95% confidence intervals (CI) to quantify the association between haptoglobin polymorphism and CAD.
- Studies were evaluated for statistical significance, with OR > 1 indicating increased risk and OR < 1 indicating protective risk.
Main Results:
- The meta-analysis included 15 studies with a total of 8,632 participants (2,988 cases, 5,644 controls).
- A significant association between haptoglobin polymorphism and CAD was observed across multiple genetic models: recessive (OR: 0.74, 95% CI: 0.60-0.92), dominant (OR: 0.82, 95% CI: 0.71-0.95), homozygote (OR: 0.70, 95% CI: 0.53-0.92), and allelic (OR: 0.80, 95% CI: 0.69-0.94).
- Subgroup analysis by ethnicity revealed a statistically significant association in the Asian population, but not in the Caucasian population.
Conclusions:
- Haptoglobin polymorphism is significantly associated with coronary artery disease (CAD) susceptibility.
- The findings suggest a protective effect of haptoglobin polymorphism against CAD, particularly pronounced in individuals of Asian descent.
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