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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
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IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
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  1. Home
  2. Serum Albumin As A Prognostic Biomarker For Febrile Neutropenia Outcome And Complications: A Prospective Observational Trial.
  1. Home
  2. Serum Albumin As A Prognostic Biomarker For Febrile Neutropenia Outcome And Complications: A Prospective Observational Trial.

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Serum Albumin as a Prognostic Biomarker for Febrile Neutropenia Outcome and Complications: A Prospective

Jelena Dimitrijević1, Marina Čalamać1, Ognjen Đurmez1

  • 1Institute for Oncology and Radiology of Serbia, Belgrade, Serbia.

Clinical Medicine Insights. Oncology
|September 26, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Serum albumin shows promise as a biomarker for predicting outcomes in cancer patients with febrile neutropenia (FN). Adding it to the MASCC index significantly improves risk assessment for FN complications and mortality.

Keywords:
Febrile neutropeniaMASCC risk indexcancerprognostic markerserum albumin

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Area of Science:

  • Oncology
  • Hematology
  • Clinical Medicine

Background:

  • Febrile neutropenia (FN) is a common and serious complication of cancer therapy.
  • Accurate prediction of FN outcomes is vital for effective patient management.
  • Biomarkers like procalcitonin and albumin are being investigated for their prognostic value in FN.

Purpose of the Study:

  • To evaluate the prognostic utility of serum albumin levels in patients with febrile neutropenia.
  • To assess the impact of incorporating serum albumin into the Multinational Association for Supportive Care in Cancer (MASCC) risk index for improved risk stratification.

Main Methods:

  • A prospective observational study involving 185 adult cancer patients with FN episodes.
  • Measurement of serum albumin levels.
  • Integration of serum albumin data into the MASCC risk index.
  • Main Results:

    • Serum albumin demonstrated moderate specificity and sensitivity in predicting FN and 28-day mortality.
    • Serum albumin was an independent predictor of gastrointestinal infections.
    • Incorporating serum albumin into the MASCC index improved predictive accuracy for FN mortality (50%), 28-day mortality (66.67%), and respiratory tract infections (62.50%).

    Conclusions:

    • Serum albumin is a valuable prognostic biomarker for FN.
    • Integrating serum albumin into the MASCC risk index enhances the prediction of FN-related complications and mortality.
    • Further research is needed to optimize the clinical utility of serum albumin in FN management.