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T Cell Types and Functions

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

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Oncology And Carcinogenesis
Predictive And Prognostic Markers
The Prognostic Value Of Th17/treg Cell In Cervical Cancer: A Systematic Review And Meta-analysis.

Home
Research Domains
Biomedical And Clinical Sciences
Oncology And Carcinogenesis
Predictive And Prognostic Markers
The Prognostic Value Of Th17/treg Cell In Cervical Cancer: A Systematic Review And Meta-analysis.

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Published on: July 29, 2017

The prognostic value of Th17/Treg cell in cervical cancer: a systematic review and meta-analysis.

Jingwei Zhang¹, Jijie Zhan¹, Ziting Guan¹

¹Department of Gynecology, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China.

Frontiers in Oncology

|September 26, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Regulatory T cells (Treg) and T helper 17 (Th17) cells impact cervical cancer prognosis. High Treg levels correlate with shorter survival, while elevated Th17 cells link to advanced disease and metastasis.

Keywords:

Th17 cells prognosis regulatory T-lymphocytes uterine cervical dysplasia

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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

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Published on: September 26, 2013

Area of Science:

Immunology
Oncology
Cell Biology

Background:

The prognostic role of regulatory T cells (Treg) and T helper 17 (Th17) cells in cervical cancer is debated.
Their ratio (Th17/Treg) significance in cervical cancer progression requires further clarification.

Purpose of the Study:

To comprehensively meta-analyze the association between Treg cells, Th17 cells, their ratio, and patient survival in cervical cancer.
To clarify the prognostic significance of these immune cells in cervical cancer clinical outcomes.

Main Methods:

A systematic literature search was conducted across PubMed, Embase, and Web of Science.
Included studies focused on cervical cancer and analyzed Treg or Th17 cells.
Hazard Ratios for survival and mean/SD for clinical characteristics were extracted.

uterine cervical neoplasms

Main Results:

High Treg cell levels correlated with reduced overall survival in cervical cancer patients.
Treg cells were associated with clinical staging, independent of source or definition.
High-grade Th17 cells linked to lymphatic metastasis and advanced stage.
The Th17/Treg ratio was elevated in cervical intraepithelial neoplasia and cervical cancer.

Conclusions:

Treg cells play a significant role in cervical cancer onset and progression.
Findings offer insights into the potential of Treg and Th17 cells in cervical cancer immunotherapy.
Further research is warranted despite study heterogeneity.