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Higher atherogenic index of plasma is associated with intradialytic hypotension: a multicenter cross-sectional study

Yanzhe Peng1,2, Dan Shuai3, Yuqi Yang2

  • 1School of Clinical Medicine, Guizhou Medical University, Guiyang, China.

Renal Failure
|September 26, 2024
PubMed

Insights

Patients on maintenance hemodialysis (MHD) with elevated Atherogenic Index of Plasma (AIP) have a higher risk of intradialytic hypotension (IDH). This study found a significant association between higher AIP levels and increased odds of IDH in MHD patients.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Biochemistry

Background:

  • Intradialytic hypotension (IDH) is a common complication in maintenance hemodialysis (MHD) patients.
  • The Atherogenic Index of Plasma (AIP) is linked to cardiovascular diseases, but its association with IDH is not well understood.

Purpose of the Study:

  • To investigate the relationship between AIP levels and the occurrence of IDH in MHD patients.

Main Methods:

  • A multi-center, cross-sectional study included 1946 MHD patients across twenty dialysis centers.
  • Patients were stratified into four groups based on AIP quartiles.
  • Linear and multiple logistic regression models were employed to analyze the AIP-IDH association, with subgroup analyses performed.

Main Results:

  • An increase in AIP was significantly associated with a higher likelihood of IDH, even after adjusting for confounding factors.
  • Patients in higher AIP quartiles demonstrated a progressively increased odds of IDH compared to the lowest quartile.
  • No significant interactions were found in subgroup analyses based on age, sex, diabetes, heart failure, or myocardial infarction history.

Conclusions:

  • Elevated AIP levels are independently associated with an increased risk of intradialytic hypotension in patients undergoing maintenance hemodialysis.
Abstract

Keywords:
Intradialytic hypotensionatherogenic index of plasmacross-sectionalmaintenance hemodialysis

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