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Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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Pulmonary Tuberculosis I01:29

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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
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Overview
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  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Immunosuppression Regimen And Latitude Impact Keratinocyte Carcinoma Risk In U.s. Liver Transplant Recipients

Immunosuppression regimen and latitude impact keratinocyte carcinoma risk in U.S. liver transplant recipients

Benjamin E Rosenthal1, Douglas E Schaubel2, James D Lewis2,3

  • 1Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Archives of Dermatological Research
|September 26, 2024

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Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
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View abstract on PubMed

Summary
This summary is machine-generated.

Liver transplant recipients on calcineurin inhibitor and anti-metabolite immunosuppression face higher keratinocyte carcinoma risk. Living in southern latitudes also increases this risk, informing post-transplant care.

Area of Science:

  • Transplantation immunology
  • Dermatology
  • Epidemiology

Background:

  • Solid organ transplantation requires immunosuppression, increasing cancer risk.
  • Keratinocyte carcinoma (KC) risk is elevated post-transplant but understudied in liver transplant (LT) recipients.
  • Immunosuppression regimens and geographic latitude are potential KC risk factors in LT patients.

Purpose of the Study:

  • To investigate the association between immunosuppression regimen, latitude, and incident KC risk in LT recipients.
  • To identify specific immunosuppressive agents and geographic factors contributing to KC development post-LT.
  • To inform targeted screening and management strategies for KC in the LT population.

Main Methods:

  • Retrospective cohort study of 9,966 adult first LT recipients (2007-2016).
Keywords:
ImmunosuppressionKeratinocyte carcinomaLatitudeLiver transplantation

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  • Utilized linked Organ Procurement and Transplantation Network and Medicare data.
  • Analyzed incident de novo KC using adjusted Cox regression, considering immunosuppression and latitude.

    • Main Results:

    • Calcineurin inhibitor (CNI) with anti-metabolite combination immunosuppression was independently associated with increased KC risk (aHR 1.21-1.61).
    • Southern latitude of residence (closer to the Equator) was also independently associated with higher KC incidence (aHR 1.26 per 5°N decrease).
    • Both immunosuppression type and latitude demonstrated independent effects on post-LT KC risk.

    Conclusions:

    • CNI with anti-metabolite immunosuppression regimens increase KC risk in LT recipients.
    • Geographic latitude significantly influences KC risk, with lower latitudes associated with higher incidence.
    • Findings support personalized screening and immunosuppression management strategies for LT patients to mitigate KC risk.