JoVE - Journal of Visualized Experiments
JoVE Visualize
Contact Us

The potential of flavonoids to mitigate cellular senescence in cardiovascular disease

  • 0School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, 210094, Jiangsu, People's Republic of China.
Biogerontology +

|

September 26, 2024

|

September 26, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Cellular senescence, a key aging factor, drives cardiovascular disease (CVD) via SASP. Flavonoids show promise in targeting senescent cells (SCs) and SASP to combat CVD.

Area Of Science

  • Cardiovascular Science
  • Gerontology
  • Molecular Biology

Background

  • Cellular senescence is a hallmark of aging impacting cardiovascular health.
  • Senescent cells (SCs) secrete senescence-associated secretory phenotype (SASP), exacerbating age-related diseases like cardiovascular diseases (CVD).
  • Targeting SCs via anti-aging therapies is a novel strategy for cardiovascular disease management.

Purpose Of The Study

  • To review the role of cellular senescence in CVD development.
  • To explore the potential of flavonoids in targeting SCs and SASP for CVD prevention and treatment.
  • To provide insights for developing flavonoid-based cardiovascular therapies.

Main Methods

  • Literature review on cellular senescence, SASP, and CVD.
  • Analysis of existing research on flavonoids' effects on SCs and SASP.
  • Synthesis of evidence linking flavonoid actions to CVD reduction.

Main Results

  • Cellular senescence and SASP significantly contribute to CVD pathogenesis.
  • Flavonoids possess senolytic and senomorphic properties beneficial for CVD.
  • Evidence suggests flavonoids can modulate SCs and SASP to mitigate CVD.

Conclusions

  • Flavonoids represent a promising therapeutic avenue for CVD by targeting cellular senescence.
  • Further research is needed to fully elucidate and leverage flavonoid mechanisms in cardiovascular health.
  • This review highlights the potential of flavonoids for drug design and clinical application in CVD.

Keywords:

Related Concept Videos

Cancer Prevention 02:59

6.1K

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...

Mitochondria 01:37

11.4K

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...

Aging 01:26

39

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

Replicative Cell Senescence 02:15

3.6K

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...

Electron Transport Chain: Complex I and II 01:46

12.2K

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...

Coronary Artery Disease I: Introduction 01:30

3

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...