Oral Microbiome and Subsequent Risk of Head and Neck Squamous Cell Cancer
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View abstract on PubMed
Summary
This summary is machine-generated.Oral bacteria, not fungi, are linked to head and neck squamous cell cancer (HNSCC) risk. Specific bacterial species and complexes increase HNSCC development, aiding personalized prevention strategies.
Area Of Science
- Microbiology
- Oncology
- Epidemiology
Background
- The oral microbiome's role in head and neck squamous cell cancer (HNSCC) is under investigation, with limited evidence from small studies.
- Existing research primarily relies on bacterial 16S amplicon sequencing.
Purpose Of The Study
- To determine if oral bacterial and fungal microbiomes are associated with the subsequent risk of developing HNSCC.
- To identify specific microbial risk factors for HNSCC.
Main Methods
- A prospective nested case-control study was conducted across three large epidemiological cohorts.
- Oral samples were analyzed using whole-genome shotgun sequencing for bacteria and internal transcribed spacer sequencing for fungi.
- Associations were assessed using compositional analysis and logistic regression, with a microbial risk score developed.
Main Results
- No association was found between overall oral microbiome diversity and HNSCC risk.
- Thirteen oral bacterial species, including Prevotella salivae and Streptococcus sanguinis, were differentially associated with HNSCC development.
- The red/orange periodontal pathogen complex showed a moderate association with HNSCC risk, and a microbial risk score based on 22 bacteria increased HNSCC risk by 50%.
Conclusions
- Oral bacteria, but not fungi, are compellingly linked as a risk factor for HNSCC development.
- Identified bacteria and complexes can contribute to personalized HNSCC prevention strategies.
- Further research can integrate these microbial findings with other risk factors for improved risk stratification.
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