New challenges in scar therapy: the novel scar therapy strategies based on nanotechnology
Zhuoyang Chen1, Jia Gao2, Lili Li2
1The second clinical college, China Medical University, Shenyang, PR China.
Abstract:
The pathological mechanism of pathological scar is highly complex, encompassing the abnormalities of diverse cytokines, signaling pathways and regulatory factors. To discover more preferable scar treatment options, a variety of distinct approaches have been utilized clinically. Nevertheless, these treatments possess certain side effects and are inclined to relapse. Presently, pathological scar treatment remains a clinical conundrum, and there is an urgent demand for treatment methods that are safe, less traumatic and have lower recurrence rates. New drug delivery systems, novel therapeutic drugs and therapy strategies can enable drugs to permeate the skin effectively, decrease side effects, enhance drug efficacy and even achieve pain-free self-administration. Currently, novel nanotechnologies such as nanomicroneedles, photodynamics mediated by novel photosensitizers, bioelectrical stimulation and 3D printed dressings have been developed for the effective treatment of pathological scars. Additionally, innovative nanoscale fillers, including nano-fat and engineered exosomes, can serve as novel therapeutic agents for the efficient treatment of pathological scars. The intervention of nanomaterials can enhance drug absorption, stabilize and safeguard the active ingredients of drugs, delay or control drug release and enhance bioavailability. This article reviews these new treatment strategies for scar to explore novel approaches for efficient and safe for keloid treatment.
Insights
Novel nanotechnology and nanomaterials offer promising solutions for pathological scar treatment, addressing limitations of current therapies by enhancing drug delivery, reducing side effects, and improving efficacy for keloid treatment.
Area of Science:
- Regenerative Medicine
- Biomaterials Science
- Dermatology
Background:
- Pathological scar formation involves complex molecular mechanisms, including dysregulated cytokines and signaling pathways.
- Current clinical treatments for pathological scars often have side effects and high recurrence rates, necessitating safer, less invasive options.
Purpose of the Study:
- To review emerging nanotechnology-based treatment strategies for pathological scars.
- To explore novel therapeutic approaches for efficient and safe keloid treatment.
Main Methods:
- Review of recent advancements in nanotechnologies for scar treatment, including nanomicroneedles, photodynamic therapy, bioelectrical stimulation, and 3D printed dressings.
- Examination of innovative nanoscale fillers like nano-fat and engineered exosomes as therapeutic agents.
- Discussion on the role of nanomaterials in enhancing drug absorption, stability, controlled release, and bioavailability.
Main Results:
- Nanotechnologies demonstrate potential for effective pathological scar treatment by improving drug penetration and efficacy.
- Nanoscale fillers offer novel therapeutic avenues for scar management.
- Nanomaterials significantly enhance drug delivery systems, leading to improved therapeutic outcomes.
Conclusions:
- Nanotechnology-based strategies represent a significant advancement in pathological scar and keloid treatment.
- These innovative approaches promise safer, more effective, and less recurrent scar therapies.
- Further research into nanomedicine holds potential for overcoming current clinical challenges in scar management.
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