Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Evidence for Evolution02:55

The Evidence for Evolution

42.6K
Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
42.6K
Evolutionary Psychology01:20

Evolutionary Psychology

255
Evolutionary psychology explores the origins of human behavior and mental processes by framing them within the context of natural selection, a theory famously propounded by Charles Darwin. This field asserts that many behaviors common across human societies — ranging from instinctive fear reactions to complex social interactions — arose as evolutionary adaptations. These adaptations enhanced the survival and reproductive success of our ancestors, thereby becoming embedded in the...
255
Viral Mutations00:36

Viral Mutations

32.2K
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
32.2K
Convergent Evolution01:54

Convergent Evolution

27.6K
Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.
27.6K
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

5.7K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.7K
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

7.0K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
7.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Desmoglein-2 Deficiency Drives Mitochondrial Morphological Remodeling in Cardiomyocytes.

American journal of physiology. Heart and circulatory physiology·2026
Same author

Porcine Left Atrial and Ventricular Thick Filaments Exhibit Distinct Resting Structures and Calcium-dependent Responses.

bioRxiv : the preprint server for biology·2026
Same author

Myosin Filaments of Vertebrate Skeletal and Cardiac Muscle are Highly Similar, but not Identical.

bioRxiv : the preprint server for biology·2026
Same author

Phenotype specific nuclear lamina remodeling in hiPSC derived cardiomyocytes bearing <i>TNNT2</i> sarcomeric variants.

iScience·2025
Same author

Desmoglein-2 deficiency results in cardiac dysfunction by compromising both Z-disc- and intercalated disc-mediated mechanotransduction.

bioRxiv : the preprint server for biology·2025
Same author

Cardiac Troponin C E135A Variant Impairs Myofilament Response to PKA Phosphorylation and Is Associated With Autosomal Dominant Dilated Cardiomyopathy With Diastolic Dysfunction.

Circulation. Genomic and precision medicine·2025

Related Experiment Video

Updated: Jun 12, 2025

Following the Dynamics of Structural Variants in Experimentally Evolved Populations
04:52

Following the Dynamics of Structural Variants in Experimentally Evolved Populations

Published on: February 3, 2023

925

Can evolution-based studies inform modern medicine?

Maicon Landim-Vieira1, Jose Renato Pinto1

  • 1Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL, USA.

Science (New York, N.Y.)
|September 26, 2024
PubMed
Summary
This summary is machine-generated.

Comparative genomic analyses reveal key mechanisms underlying cardiac muscle regulation. This research offers insights into how heart muscle functions and is controlled at a genetic level.

More Related Videos

Daily Transfers, Archiving Populations, and Measuring Fitness in the Long-Term Evolution Experiment with Escherichia coli
15:00

Daily Transfers, Archiving Populations, and Measuring Fitness in the Long-Term Evolution Experiment with Escherichia coli

Published on: August 18, 2023

3.2K
Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance
09:00

Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance

Published on: May 2, 2018

11.7K

Related Experiment Videos

Last Updated: Jun 12, 2025

Following the Dynamics of Structural Variants in Experimentally Evolved Populations
04:52

Following the Dynamics of Structural Variants in Experimentally Evolved Populations

Published on: February 3, 2023

925
Daily Transfers, Archiving Populations, and Measuring Fitness in the Long-Term Evolution Experiment with Escherichia coli
15:00

Daily Transfers, Archiving Populations, and Measuring Fitness in the Long-Term Evolution Experiment with Escherichia coli

Published on: August 18, 2023

3.2K
Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance
09:00

Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance

Published on: May 2, 2018

11.7K

Area of Science:

  • Genomics
  • Cardiology
  • Molecular Biology

Background:

  • Cardiac muscle regulation is complex, involving intricate genetic pathways.
  • Understanding these pathways is crucial for diagnosing and treating heart conditions.

Purpose of the Study:

  • To elucidate the genetic underpinnings of cardiac muscle regulation.
  • To identify novel genes and mechanisms involved in heart muscle function.

Main Methods:

  • Comparative genomic analysis of multiple species.
  • Bioinformatic approaches to identify conserved regulatory elements.
  • Functional validation of candidate genes in cardiac models.

Main Results:

  • Identification of conserved non-coding elements associated with cardiac gene expression.
  • Discovery of novel transcription factors regulating key cardiac proteins.
  • Demonstration of functional roles for identified genes in cardiac contractility.

Conclusions:

  • Comparative genomics is a powerful tool for uncovering cardiac regulatory mechanisms.
  • The identified genes and pathways offer potential therapeutic targets for cardiac diseases.
  • This study advances our understanding of fundamental cardiac muscle biology.