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Updated: Jun 12, 2025

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
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The Role and Mechanism of Vascular Aging in Geriatric Vascular Diseases

Shouyao Zhang1, Bo Xia2, Bill Kalionis3

  • 1The Second Clinical Medical College, The Second Affiliated Hospital, Yunnan University of Chinese Medicine, Kunming, China.

Aging and Disease
|September 26, 2024
PubMed

Insights

Vascular aging drives organ system decline and diseases like atherosclerosis in older adults. Strategies targeting endothelial repair and reducing inflammation can counter these aging effects for healthier longevity.

Area of Science:

  • Gerontology and Cardiovascular Science
  • Pathophysiology of Aging

Background:

  • Vascular aging is a primary driver of organ system senescence and age-related diseases, including atherosclerosis and Alzheimer's.
  • Key aging indicators include increased pulse wave velocity, carotid intima-media thickening, and reduced vascular dilation.

Purpose of the Study:

  • To explore the molecular mechanisms and biomarkers associated with vascular aging.
  • To identify potential therapeutic targets for mitigating age-related vascular dysfunction and disease.

Main Methods:

  • Review of signaling pathways (mTOR, AMPK, NF-κB, Klotho, SIRT) implicated in vascular aging.
  • Analysis of biomarkers such as senescence-associated β-galactosidase, endothelial progenitor cells, microparticles, and exosomal miRNAs.

Main Results:

  • Identified key molecular pathways and biomarkers indicative of vascular aging.
  • Highlighted the role of endothelial dysfunction, oxidative stress, and mitochondrial/telomere dysfunction in the aging vasculature.

Conclusions:

  • Vascular aging research provides a foundation for developing interventions against geriatric vascular diseases.
  • Strategies focused on endothelial repair, oxidative stress reduction, and mitochondrial/telomere restoration are crucial for promoting healthy aging.

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