Related Experiment Video
Updated: Jun 12, 2025
09:39
Modeling Myotonic Dystrophy 1 in C2C12 Myoblast Cells
Published on: July 29, 2016
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Common Characteristics Between Frailty and Myotonic Dystrophy Type 1: A Narrative Review
Joana Garmendia1,2, Garazi Labayru1,2,3, Philipe de Souto Barreto4,5,6
1Department of Clinical and Health Psychology and Research Methodology, Psychology Faculty, University of the Basque Country (UPV/EHU), Donostia-San Sebastián, Gipuzkoa, Spain.
Aging and Disease
|September 26, 2024
Summary
Myotonic dystrophy type 1 (DM1) shares four frailty criteria, including muscle weakness and fatigue. Addressing frailty in DM1 patients may reduce disease burden and symptoms.
Area of Science:
- Neurology
- Gerontology
- Genetics
Background:
- Myotonic dystrophy type 1 (DM1) exhibits accelerated aging features.
- Frailty is understudied in neuromuscular disorders compared to neurological conditions.
Purpose of the Study:
- To identify common characteristics between Fried's frailty phenotype criteria and DM1.
- To explore psychological and social factors contributing to frailty in DM1.
Main Methods:
- Narrative review of existing literature.
- Analysis of DM1 clinical manifestations against frailty criteria.
- Examination of psychological and social determinants of frailty in DM1.
Main Results:
- DM1 patients frequently meet four of five frailty criteria (weakness, slow gait, weight loss, fatigue, low activity).
- These frailty markers deteriorate longitudinally in DM1.
- Psychological/cognitive and social factors exacerbate frailty in DM1.
Conclusions:
- DM1 shares significant overlap with the frailty phenotype.
- Frailty assessment in DM1 is crucial for intervention.
- Monitoring frailty may mitigate DM1's impact.
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