Related Experiment Video

Updated: Jun 12, 2025

Microelectrode Array Recording of Sinoatrial Node Firing Rate to Identify Intrinsic Cardiac Pacemaking Defects in Mice
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Microelectrode Array Recording of Sinoatrial Node Firing Rate to Identify Intrinsic Cardiac Pacemaking Defects in Mice

Published on: July 5, 2021

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Causal relationship between Brugada syndrome and electrocardiogram traits: A bidirectional Mendelian randomization

Changxi Li1, Xinquan Wu1, Xudong Song1

  • 1Department of Cardiology, Laboratory of Heart Center, Heart Center, Zhujiang Hospital, Southern Medical University, China; Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China; Guangdong Provincial Biomedical Engineering Technology Research Center for Cardiovascular Disease, Zhujiang Hospital, Southern Medical University, Guangzhou, China.

Journal of Electrocardiology
|September 26, 2024
PubMed
Summary

This study used Mendelian randomization to find causal links between Brugada syndrome (BrS) and ECG traits. BrS has bidirectional causal links with P wave duration and PR interval, and positive links with QRS duration and QT interval.

Keywords:
Bidirectional Mendelian randomizationBrugada syndromeColocalization analysisElectrocardiogram

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