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Biospecimens in the HEALthy Brain and Child Development (HBCD) Study: Rationale and protocol.

Elinor L Sullivan¹, Ryan Bogdan², Ludmila Bakhireva³

¹Departments of Psychiatry and Behavioral Neuroscience, Center for Mental Health Innovation, Oregon Health & Science University, Portland, OR, USA.

Developmental Cognitive Neuroscience

|September 26, 2024

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Summary

This summary is machine-generated.

The HEALthy Brain and Child Development (HBCD) Study collects biosamples from over 7000 parent-child pairs to investigate how prenatal and postnatal exposures impact neurodevelopmental outcomes. This research supports future studies on early life development.

Area of Science:

Neuroscience
Developmental Biology
Genetics

Background:

The HEALthy Brain and Child Development (HBCD) Study is a large, multi-site prospective longitudinal cohort study.
It aims to understand human brain development from prenatal stages through early childhood.

Purpose of the Study:

To examine the impact of prenatal and postnatal exposures on neurobehavioral development.
To facilitate research on biological processes influencing development using collected biospecimens.

Main Methods:

Longitudinal collection of biological samples from over 7000 birthing parents and their children.
Collection includes blood, nail clippings, urine, and saliva from parents; saliva, stool, and urine from children.
Additional samples like placenta tissue, cord blood, and cord tissue are collected from a subset.

Keywords:

Environmental exposures HBCD, biospecimens, substance use Prenatal, fetal programming

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Main Results:

Detailed rationale for biospecimen collection is provided.
Current and potential future uses of biospecimens are outlined.
Collection protocols and piloting success rates are described.

Conclusions:

The study provides a comprehensive framework for biospecimen collection in early life research.
This information will guide future research utilizing the HBCD biospecimen collection.
The HBCD Study's biospecimen data will advance understanding of neurodevelopmental trajectories.