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Biospecimens in the HEALthy Brain and Child Development (HBCD) Study: Rationale and protocol
Elinor L Sullivan1, Ryan Bogdan2, Ludmila Bakhireva3
1Departments of Psychiatry and Behavioral Neuroscience, Center for Mental Health Innovation, Oregon Health & Science University, Portland, OR, USA.
Developmental Cognitive Neuroscience
|September 26, 2024
Summary
The HEALthy Brain and Child Development (HBCD) Study collects biosamples from over 7000 parent-child pairs to investigate how prenatal and postnatal exposures impact neurodevelopmental outcomes. This research supports future studies on early life development.
Area of Science:
- Neuroscience
- Developmental Biology
- Genetics
Background:
- The HEALthy Brain and Child Development (HBCD) Study is a large, multi-site prospective longitudinal cohort study.
- It aims to understand human brain development from prenatal stages through early childhood.
Purpose of the Study:
- To examine the impact of prenatal and postnatal exposures on neurobehavioral development.
- To facilitate research on biological processes influencing development using collected biospecimens.
Main Methods:
- Longitudinal collection of biological samples from over 7000 birthing parents and their children.
- Collection includes blood, nail clippings, urine, and saliva from parents; saliva, stool, and urine from children.
- Additional samples like placenta tissue, cord blood, and cord tissue are collected from a subset.
Main Results:
- Detailed rationale for biospecimen collection is provided.
- Current and potential future uses of biospecimens are outlined.
- Collection protocols and piloting success rates are described.
Conclusions:
- The study provides a comprehensive framework for biospecimen collection in early life research.
- This information will guide future research utilizing the HBCD biospecimen collection.
- The HBCD Study's biospecimen data will advance understanding of neurodevelopmental trajectories.
