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Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
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Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA
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Serum dsDNA is environmentally contingent.

Qi Zhen1, Weiwei Chen1, Yang Han1

  • 1North China University of Science and Technology Affiliated Hospital, Thangshan 063000, China; Inflammation and Immune Diseases Laboratory of North China University of Science and Technology, Tangshan 063210, China; Health Science Center, North China University of Science and Technology, Tangshan 063210, China; Key Laboratory for quality of salt alkali resistant TCM of Hebei Administration of TCM, North China University of Science and Technology, Tangshan, 063210, China.

International Immunopharmacology
|September 26, 2024
PubMed
Summary
This summary is machine-generated.

Climate impacts autoimmune diseases like psoriasis. This study found that serum double-stranded DNA (dsDNA) levels, linked to psoriasis, vary significantly with season and latitude across China.

Keywords:
Autoimmune diseaseDouble-stranded DNAEnvironmentPsoriasis

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Area of Science:

  • Immunology
  • Environmental Health
  • Dermatology

Background:

  • Psoriasis is an autoimmune disease with known seasonal and latitudinal variations.
  • Double-stranded DNA (dsDNA) is implicated in innate immune responses and autoimmune triggers.
  • Understanding environmental influences on dsDNA levels is crucial for autoimmune disease research.

Purpose of the Study:

  • To quantitatively analyze serum dsDNA levels in relation to season and latitude in China.
  • To investigate the association between climatic factors and dsDNA concentrations in a large population cohort.
  • To explore potential links between environmental variables and autoimmune disease markers.

Main Methods:

  • A case-control study involving 10,110 psoriasis patients and matched controls.
  • Data collected from 12 regions across China between 2016 and 2020.
  • Analysis of serum dsDNA levels correlated with geographical, climatic, and seasonal data.

Main Results:

  • Serum dsDNA levels were significantly higher in Northern China compared to the South.
  • Medium latitude regions and areas with lower UV exposure showed elevated dsDNA levels.
  • Winter season and longer daylight hours were associated with increased serum dsDNA concentrations.

Conclusions:

  • Geographical location, season, and climatic conditions significantly influence serum dsDNA levels.
  • Environmental factors like latitude, UV index, and season may play a role in modulating dsDNA concentrations relevant to autoimmune conditions.
  • Further research into climate-driven immune responses in psoriasis is warranted.