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Updated: Jun 12, 2025

Author Spotlight: Discovering New Biopesticides from Bioactive Soil Microbe-Derived Natural Products
Published on: July 26, 2024
Modification of natural compounds through biotransformation process by microorganisms and their pharmacological
Nigora Rustamova1, Guozheng Huang2, Maksud Isokov3
1State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China; Department of Enzymology, Institute of Microbiology, Academy of Sciences of the Republic of Uzbekistan, Tashkent, Shaykhantakhur district, street Abdulla Kadiriy, 7 B100128, Uzbekistan; Department of Biology, Samarkand State University, University Boulevard 15, Samarkand 703004, Uzbekistan.
Abstract:
The biotransformation of natural compounds by fungal microorganisms is a complex biochemical process. Tandem whole-cell biotransformation offers a promising, alternative, and cost-effective method for modifying of bioactive novel compounds. This approach is particularly beneficial for structurally complex natural products that are difficult to be synthesized through traditional synthetic methods. Biotransformation also provides significant regio- and stereoselectivity, making it a valuable tool for the chemical modification of natural compounds. By utilizing microbial conversion reactions, the biological activity and structural diversity of natural products can be enhanced. In this review, we have summarized 282 novel metabolites resulting from microbial transformation by various microorganisms. We discussed the chemical structures and pharmacological properties of these novel biotransformation products. The review would assist scientists working in the fields of biotechnology, organic chemistry, medicinal chemistry, and pharmacology.
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