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Updated: Jun 12, 2025

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Oncogenic potential of SARS-CoV-2-targeting hallmarks of cancer pathways

Aishwarya Jaiswal1, Sanah Shrivastav2, Hemant R Kushwaha3,4

  • 1Cancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, 110067, India.

Cell Communication and Signaling : CCS
|September 26, 2024
PubMed

Insights

The SARS-CoV-2 virus, responsible for COVID-19, may promote cancer development by interfering with tumor suppressor genes and activating cancer-promoting pathways. Understanding this link is crucial for managing both viral infections and cancer consequences.

Area of Science:

  • Oncology
  • Virology
  • Molecular Biology

Background:

  • The SARS-CoV-2 pandemic presents a global health crisis.
  • Emerging evidence suggests a potential link between SARS-CoV-2 infection and cancer development (carcinogenesis).

Purpose of the Study:

  • To review the mechanisms by which SARS-CoV-2 proteins may influence oncogenic pathways.
  • To explore the potential of SARS-CoV-2 as an oncovirus and its role in cancer hallmarks.

Main Methods:

  • Review of recent bioinformatic and experimental studies.
  • Analysis of viral protein interactions with cellular components involved in cancer.

Main Results:

  • SARS-CoV-2 proteins can alter key signaling pathways associated with cancer hallmarks.
  • The virus appears to inhibit tumor suppressor genes/pathways while promoting survival, proliferation, and inflammation.

Conclusions:

  • SARS-CoV-2 may contribute to tumorigenesis through novel mechanisms distinct from classical oncogenic viruses.
  • Elucidating these interactions is vital for understanding COVID-19 and cancer biology and developing mitigation strategies.
Keywords:
COVID-19Cancer hallmarksCoronavirusOncovirusTumorigenesis

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