Inflammatory spindle cell PEComa of the lung with YAP1::TFE3 fusion: a report of two cases and a potential relationship with clear cell stromal tumour
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View abstract on PubMed
Summary
This summary is machine-generated.Two lung tumors with myomelanocytic differentiation and YAP1::TFE3 fusion were identified. These findings suggest a distinct subset of perivascular epithelioid cell tumors (PEComa) and a potential link to clear cell stromal tumors of the lung (CCST-L).
Area Of Science
- Oncology
- Genetics
- Pathology
Background
- Perivascular epithelioid cell tumors (PEComa) are characterized by specific cellular morphology and differentiation.
- A subset of PEComa harbors TFE3 fusions, but YAP1::TFE3 fusion has not been previously reported.
- Clear cell stromal tumor of the lung (CCST-L) is an emerging entity with distinct histological and molecular features, including YAP1::TFE3 fusion.
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