Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Central hypothyroidism and hyperthyroidism.

C H Emerson

    The Medical Clinics of North America
    |September 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Central hypothyroidism results from hypothalamic or pituitary disease, leading to TSH deficiency. Diagnosis requires thyroid function tests, and treatment involves managing hormone deficiencies and associated conditions.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Neuropeptide Y has a central inhibitory action on the hypothalamic-pituitary-thyroid axis.

    Endocrinology·2001
    Same author

    Effect of various doses of recombinant human thyrotropin on the thyroid radioactive iodine uptake and serum levels of thyroid hormones and thyroglobulin in normal subjects.

    The Journal of clinical endocrinology and metabolism·2001
    Same author

    The effect of recombinant human tsh on the thyroid (123)i uptake in iodide treated normal subjects.

    The Journal of clinical endocrinology and metabolism·2001
    Same author

    alpha-Melanocyte-stimulating hormone is contained in nerve terminals innervating thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus and prevents fasting-induced suppression of prothyrotropin-releasing hormone gene expression.

    The Journal of neuroscience : the official journal of the Society for Neuroscience·2000
    Same author

    Association of cocaine- and amphetamine-regulated transcript-immunoreactive elements with thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus and its role in the regulation of the hypothalamic-pituitary-thyroid axis during fasting.

    The Journal of neuroscience : the official journal of the Society for Neuroscience·2000
    Same author

    The effect of recombinant human thyrotropin (rhTSH) on thyroid function in mice and rats.

    Thyroid : official journal of the American Thyroid Association·1998
    Same journal

    Care Transitions Continue to Evolve.

    The Medical clinics of North America·2026
    Same journal

    Navigating the Gaps: A Comprehensive Overview of Care Transitions Across the Continuum.

    The Medical clinics of North America·2026
    Same journal

    Care Transitions and Value-Based Payment Models in the United States.

    The Medical clinics of North America·2026
    Same journal

    Technology and Innovation in Care Transitions: Imagining the Future of Postdischarge Care.

    The Medical clinics of North America·2026
    Same journal

    Primary Care, Specialists, and Hospitals: Bridging the Gaps in Communication and Coordination.

    The Medical clinics of North America·2026
    Same journal

    Social Determinants of Health: Unique Considerations in Transitions of Care.

    The Medical clinics of North America·2026
    See all related articles

    Area of Science:

    • Endocrinology
    • Neuroendocrinology
    • Thyroidology

    Background:

    • Thyroid-stimulating hormone (TSH) secretion by the pituitary, regulated by hypothalamic thyrotropin-releasing hormone (TRH), maintains thyroid function.
    • Hypothalamic and pituitary diseases often disrupt this axis, causing central hypothyroidism.
    • Thyroid hormone resistance, a rare cause of hyperthyroidism, necessitates careful diagnosis to avoid contraindicating treatments.

    Observation:

    • Serum TSH levels in central hypothyroidism can be inappropriately low or even normal, sometimes due to biologically inactive TSH.
    • TSH-secreting pituitary tumors, though rare, can cause hyperthyroidism and are often large and invasive.
    • Selective pituitary resistance to thyroid hormone is the most frequent cause of functional TSH-induced hyperthyroidism.

    Findings:

    Related Experiment Videos

    • Thyroid function tests, including TSH radioimmunoassay (RIA), are crucial for diagnosing central hypothyroidism in patients with pituitary or hypothalamic disease.
    • The TSH RIA may not always be undetectable in central hypothyroidism and can be within the high normal range.
    • Distinguishing between different causes of abnormal TSH secretion is essential for appropriate patient management.

    Implications:

    • Management of central hypothyroidism requires addressing co-existing pituitary hormone deficiencies, such as secondary adrenal failure.
    • Accurate diagnosis of TSH-mediated hyperthyroidism is vital, particularly ruling out generalized thyroid hormone resistance before initiating antithyroid therapies.
    • Understanding the nuances of TSH secretion and action is critical for effective diagnosis and treatment of thyroid dysfunction.