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Assessment and Communication for People with Disorders of Consciousness

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Published on: August 1, 2017

Validation of the imperial psychedelic predictor scale.

Michael Angyus¹, Sarah Osborn¹, Eline Haijen^1,2

¹Department of Brain Sciences, Centre for Psychedelic Research, Imperial College London, London, UK.

Psychological Medicine

|September 27, 2024

Summary

The Imperial Psychedelic Predictor Scale (IPPS) effectively predicts key aspects of psychedelic experiences, including mystical and challenging effects. This validated 9-item scale aids in understanding psychedelic preparedness for safety and therapeutic potential.

Keywords:

pharmaceuticals predicting psychedelic response psychedelic preparation psychedelics psychometrics safety set and setting

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Area of Science:

Psychopharmacology
Clinical Psychology
Neuroscience

Background:

Psychedelic drug responses are unpredictable, necessitating improved prediction methods for safety and therapeutic optimization.
The liberalization of access to psychedelic substances underscores the need for validated predictive tools.
The Imperial Psychedelic Predictor Scale (IPPS) was developed as a prospective measure for psychedelic experience dimensions.

Purpose of the Study:

To validate the Imperial Psychedelic Predictor Scale (IPPS) as a predictive measure of acute psychedelic experiences.
To assess the construct, predictive, and convergent validity of the IPPS across diverse datasets.
To establish the IPPS's utility in both naturalistic and controlled psychedelic use settings.

Main Methods:

Utilized four independent datasets, including online surveys (N=741, N=836) and controlled administration studies (N=30, N=28).
Conducted factor analysis, regression, and correlation analyses to evaluate the IPPS.
Assessed the internal consistency and factor structure of the developed 9-item scale.

Main Results:

The 9-item IPPS demonstrated good internal consistency (Cronbach's α = 0.8) and comprised three factors: set, rapport, and intention.
The IPPS significantly predicted 'mystical', 'challenging', and 'emotional breakthrough' experiences.
Set and rapport explained 40% of the variance in mystical experiences in a controlled setting; set explained 16% of challenging experiences; rapport explained 9% of emotional breakthrough experiences.

Conclusions:

The IPPS is a validated, brief scale predictive of key acute psychedelic experience features.
The scale shows utility across various contexts, from naturalistic use to controlled settings.
Widespread adoption of the IPPS can enhance understanding of psychedelic preparedness, improving safety and therapeutic outcomes.