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Updated: Jun 12, 2025

An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation
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Arg92Leu-cTnT Alters the cTnC-cTnI Interface Disrupting PKA-Mediated Relaxation

Melissa L Lynn1, Jesus Jimenez2, Romi L Castillo1

  • 1Department of Biomedical Engineering (M.L.L., R.L.C., C.G., J.C.T.), University of Arizona, Tucson.

Circulation Research
|September 27, 2024
PubMed
Summary

Hypertrophic cardiomyopathy (HCM) mutations cause early diastolic dysfunction by altering the cardiac troponin C-cardiac troponin I interface, reducing PKA accessibility. This molecular insight reveals a potential therapeutic target for HCM treatment.

Keywords:
calciumcardiomyopathy, hypertrophicfluorescence resonance energy transfermolecular dynamics simulationphosphorylationsarcomerestroponin

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