Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pyriphenone modification of glutaraldehyde pretreated bovine pericardium mitigates advanced glycation end products, calcification, and platelet adhesion.

Acta biomaterialia·2026
Same author

Galactic cosmic radiation produces sex-specific, circuit-selective cognitive vulnerability: countermeasure trade-offs revealed by multi-domain assessment.

Research square·2026
Same author

Size Scaling of the Electrochemical Performance of Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene Microelectrode Arrays for Electrophysiological Recording and Stimulation.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

On-demand seizures facilitate rapid screening of therapeutics for epilepsy.

eLife·2026
Same author

Circuit-selective cognitive vulnerability to environmental stress: multi-domain assessment of space radiation in both sexes reveals countermeasure trade-offs.

bioRxiv : the preprint server for biology·2026
Same author

Size Scaling of the Electrochemical Performance of Ti<sub>3</sub>C<sub>2</sub>T <sub><i>x</i></sub> MXene Microelectrode Arrays for Electrophysiological Recording and Stimulation.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Jun 12, 2025

Fabrication of Ti3C2 MXene Microelectrode Arrays for In Vivo Neural Recording
09:58

Fabrication of Ti3C2 MXene Microelectrode Arrays for In Vivo Neural Recording

Published on: February 12, 2020

13.3K

Transparent MXene Microelectrode Arrays for Multimodal Mapping of Neural Dynamics.

Sneha Shankar1,2,3, Yuzhang Chen2,3, Spencer Averbeck1,2,3

  • 1Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA.

Advanced Healthcare Materials
|September 27, 2024
PubMed
Summary

Researchers developed transparent MXene microelectrode arrays for neural sensing. These advanced arrays offer high spatiotemporal resolution for brain activity recording and enable simultaneous imaging, overcoming limitations of current transparent electrode technologies.

Keywords:
multimodal interfacesneuroelectronicsneuroengineering

More Related Videos

Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology
09:44

Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology

Published on: March 8, 2024

4.7K
Construction and Implementation of Carbon Fiber Microelectrode Arrays for Chronic and Acute In Vivo Recordings
07:37

Construction and Implementation of Carbon Fiber Microelectrode Arrays for Chronic and Acute In Vivo Recordings

Published on: August 5, 2021

3.8K

Related Experiment Videos

Last Updated: Jun 12, 2025

Fabrication of Ti3C2 MXene Microelectrode Arrays for In Vivo Neural Recording
09:58

Fabrication of Ti3C2 MXene Microelectrode Arrays for In Vivo Neural Recording

Published on: February 12, 2020

13.3K
Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology
09:44

Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology

Published on: March 8, 2024

4.7K
Construction and Implementation of Carbon Fiber Microelectrode Arrays for Chronic and Acute In Vivo Recordings
07:37

Construction and Implementation of Carbon Fiber Microelectrode Arrays for Chronic and Acute In Vivo Recordings

Published on: August 5, 2021

3.8K

Area of Science:

  • Neuroscience
  • Materials Science
  • Biomedical Engineering

Background:

  • Transparent microelectrode arrays are crucial for neural sensing, providing high spatial and temporal resolution.
  • Existing transparent electrodes face challenges in durability, transparency, low impedance, and scalable fabrication.
  • There is a need for advanced transparent electrodes that overcome these limitations for multimodal neural mapping.

Purpose of the Study:

  • To introduce artifact-resistant transparent MXene microelectrode arrays for high spatiotemporal resolution neural recording.
  • To evaluate the performance of these arrays for simultaneous electrophysiology and imaging.
  • To demonstrate their utility in preclinical models of neurological activity.

Main Methods:

  • Fabrication of transparent microelectrode arrays using Ti₃C₂Tx MXene.
  • Optical characterization (transmittance at 550 nm).
  • Electrochemical characterization (impedance, charge storage capacity).
  • In vivo electrophysiological recordings in rodent models (epileptiform activity, barrel cortex multi-unit activity).
  • Simultaneous calcium imaging and electrophysiology.

Main Results:

  • Achieved 60% transmittance at 550 nm with low impedance (563 ± 99 kΩ at 1 kHz) and high charge storage capacity (58 mC cm⁻²).
  • Successfully recorded neural activity, including seizure onset and multi-unit activity, in rodent models.
  • Demonstrated simultaneous electrophysiology and calcium imaging without light-induced artifacts.
  • Validated artifact resistance and high spatiotemporal resolution capabilities.

Conclusions:

  • Transparent MXene microelectrode arrays offer a promising solution for advanced neural sensing.
  • These arrays facilitate multimodal neural mapping by enabling simultaneous electrophysiology and optical techniques.
  • The developed technology overcomes key limitations of current transparent electrodes, paving the way for improved brain-computer interfaces and neural research tools.