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Association between serum NUCB2/nesfatin‑1 levels and erectile dysfunction.
Akif Koç1, Abdullah Gul1, Anil Erkan2
1Department of Urology, Bursa Faculty of Medicine, Health Sciences University, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa 16310, Turkey.
Experimental and Therapeutic Medicine
|September 27, 2024
Summary
Lower levels of Nucleobindin 2 (NUCB2)/nesfatin-1 are linked to erectile dysfunction (ED) in men. This study suggests NUCB2/nesfatin-1 may play a role in the development of ED.
Area of Science:
- Endocrinology
- Urology
- Molecular Biology
Background:
- Erectile dysfunction (ED) is a common male sexual health concern with complex causes.
- Nucleobindin 2 (NUCB2), also known as nesfatin-1, influences vascular, neural, and hormonal systems relevant to ED.
- The precise role of NUCB2/nesfatin-1 in ED etiology requires further investigation.
Purpose of the Study:
- To investigate the association between serum NUCB2/nesfatin-1 levels and the presence and severity of erectile dysfunction.
- To compare NUCB2/nesfatin-1 levels in men with and without ED.
Main Methods:
- A case-control study involving 43 men with ED and 40 healthy controls.
- Assessment of ED severity using the International Index of Erectile Function (IIEF-5).
- Measurement of serum NUCB2/nesfatin-1 and various biochemical markers, including testosterone and lipids.
Main Results:
- Serum NUCB2/nesfatin-1 levels were significantly lower in the ED group compared to the non-ED group (P=0.019).
- A weak negative correlation was observed between serum NUCB2/nesfatin-1 levels and ED severity (r=-0.306; P=0.005).
- A cut-off value of 1.25 ng/ml for serum NUCB2/nesfatin-1 effectively distinguished between ED and non-ED groups.
Conclusions:
- Reduced serum NUCB2/nesfatin-1 levels may be implicated in the pathogenesis of erectile dysfunction.
- NUCB2/nesfatin-1 warrants further research regarding its impact on vascular and erectile physiology.
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