ENFORCER, internet-based interventions for cardiac arrest survivors: A study protocol for a randomised,...

Area of Science:

• Cardiology
• Neurology
• Psychiatry

Background:

• Out-of-hospital cardiac arrest (OHCA) poses significant health risks in Europe, causing mortality and long-term cognitive and emotional deficits in survivors.
• Current post-discharge care for OHCA survivors is inconsistent, often failing to address disabling cognitive and emotional symptoms.
• Survivors experience reduced quality of life due to cognitive impairment, anxiety, and depression.

Purpose of the Study:

• To evaluate the effectiveness of a comprehensive, internet-based lifestyle intervention for OHCA survivors.
• To enhance the health and quality of life of OHCA survivors by addressing cognitive and emotional deficits.
• To establish a standardized, accessible, and cost-effective post-discharge care model for OHCA survivors.

Main Methods:

• A multicentre, parallel-group randomized controlled trial (ENFORCER) involving OHCA survivors aged 18-80 years.
• Participants with cognitive impairment or anxiety/depression were randomized 1:1 to an intervention or standard care group.
• The intervention group received a one-year program via a secure web application for cognitive, emotional, and physical rehabilitation.

Main Results:

• The primary outcome is the proportion of patients without cognitive or emotional symptoms at one year.
• Secondary outcomes include changes in cognitive/emotional symptoms, quality of life, sleep, and sexual function.
• Caregiver burden and well-being were also assessed as secondary outcomes.

Conclusions:

• The ENFORCER trial addresses critical gaps in post-OHCA survivor care, focusing on cognitive and emotional recovery.
• An internet-based intervention offers a scalable, cost-effective solution for improving long-term outcomes for OHCA survivors.
• Study findings may establish a new standard for post-OHCA care, improving survivor recovery and quality of life.