Noradrenaline modulates sensory information in mouse vomeronasal sensory neurons

During the induction of the body's alert state, the sympathetic system modulates sensory modalities and fine-tunes peripheral organs for improved stimulus detection. We explored noradrenaline (NA)'s role in modulating signaling in vomeronasal sensory neurons (VSNs), responsible for detecting pheromones and other semiochemicals. In current-clamp recordings, NA increased the firing frequency in response to natural stimuli of responsive VSNs and induced spiking activity in previously unresponsive neurons. Current injections into VSNs showed an increase in firing frequency during NA application. Combining transcriptomic analysis, electrophysiology, Ca²⁺ imaging, and a pharmacological approach, we identified alpha 1 adrenergic receptors as crucial for NA-induced firing frequency increases in VSNs. Immunohistochemistry revealed catecholaminergic fibers in the vomeronasal sensory epithelium, suggesting localized NA release near VSNs. This study unveils NA as a key regulator of VSN signaling, shedding light on the intricate interplay between the sympathetic nervous system and chemosensory processing, advancing our understanding of sensory modulation.