Severe Optic Neuropathy Induced by Very Prolonged Tedizolid as Suppressive Therapy: Description of a Case Report and Implication for Better Assessment
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View abstract on PubMed
Summary
This summary is machine-generated.Tedizolid, an antibiotic, may cause optic neuropathy with prolonged use, unlike linezolid. Screening for vision problems is recommended for patients on long-term tedizolid therapy.
Area Of Science
- Infectious Diseases
- Ophthalmology
- Pharmacology
Background
- Linezolid exhibits poor long-term tolerability due to mitochondrial toxicity.
- Tedizolid is considered a potential alternative for long-term suppressive antibiotic therapy.
Observation
- A case of presumed tedizolid-associated optic neuropathy is presented.
- The patient underwent prolonged tedizolid treatment for 18 months.
Findings
- This is the first reported instance of optic neuropathy linked to tedizolid.
- Mitochondrial toxicity may be a concern with extended tedizolid use.
Implications
- Ophthalmologic screening for optic neuropathy is advised for patients on prolonged tedizolid therapy.
- Further research is needed to understand the long-term safety profile of tedizolid.
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