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A modelling approach to compare ADC deconjugation and systemic elimination rates of individual drug-load species

Shawna M Hengel1, Ariel R Topletz-Erickson1, Hossam Kadry1

  • 1Clinical Pharmacology and Translational Science, Pfizer Inc, Bothell, Washington, USA.

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
|September 27, 2024
PubMed

Keywords:
Affinity capture native LC-MSMMAEMMAFcysteine conjugated ADCsdeconjugationdifferential clearancedrug to antibody ratio (DAR)pharmacokinetic model

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