Participation and Yield in Multiple Rounds of Colorectal Cancer Screening Based on Fecal Immunochemical Test: A Systematic Review and Meta-Analysis
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View abstract on PubMed
Summary
This summary is machine-generated.Participation in colorectal cancer screening increases with repeated fecal immunochemical tests, but the detection rate of advanced neoplasia declines over time. Tailoring screening intervals may improve efficiency.
Area Of Science
- Gastroenterology
- Oncology
- Public Health
Background
- Limited evidence exists on cumulative participation and yield in multi-round colorectal cancer (CRC) screening using fecal immunochemical tests (FIT).
- Understanding trends in participation and advanced neoplasm detection across screening rounds is crucial for optimizing CRC screening programs.
Purpose Of The Study
- To assess trends in participation and advanced colorectal neoplasm detection rates in multi-round FIT-based CRC screening.
- To compare these trends under different screening intervals (annual vs. biennial).
Main Methods
- Systematic literature search of PubMed, Embase, and Cochrane databases (2002-2024).
- Synthesis of participation and advanced colorectal neoplasm detection rates for each screening round.
- Calculation of 95% confidence intervals (CIs) for synthesized rates.
Main Results
- Nineteen studies with 2,296,071 participants were analyzed.
- Participation increased gradually with screening rounds, reaching 78.45% (annual) and 74.97% (biennial).
- Cumulative detection rates for advanced colorectal neoplasms increased with rounds, but per-round detection rates declined over time.
Conclusions
- Population-based CRC screening shows a slow increase in participation but diminishing incremental benefits in detection with repeated rounds.
- Tailored screening strategies, like adjusting intervals for individuals with negative FIT results, could enhance effectiveness and cost-efficiency.
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