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Microfluidic Gastrointestinal Cell Culture Technologies-Improvements in the Past Decade
Adrian J T Teo1, Siu-Kin Ng2, Kaydeson Khoo1
1School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore 639798, Singapore.
Biosensors
|September 27, 2024
Summary
Microfluidic technologies enhance gastrointestinal cell culture with improved selectivity and cost-effectiveness. This review categorizes these advancements and explores future applications in gut health and diagnostics.
Area of Science:
- Biotechnology
- Gastroenterology
- Microfluidics
Background:
- Gastrointestinal cell culture technology has advanced significantly.
- Microfluidics offers enhanced selectivity and cost-effectiveness.
Purpose of the Study:
- To review and categorize microfluidic technologies for gastrointestinal cell culture.
- To discuss current applications and future perspectives.
Main Methods:
- Categorization of microfluidic devices: cell-culture insert, conventional, and 3D-printed.
- Discussion of improvements, companies, and applications for each category.
Main Results:
- Microfluidic integration offers significant advantages for gastrointestinal cell cultures.
- Identified three main categories of microfluidic devices.
Conclusions:
- Microfluidics represents a major contribution to gastrointestinal cell culture advancements.
- Future directions include stool-derived communities, gut-immune-tumor axis, modular systems, and point-of-care diagnostics.
