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Updated: Jun 12, 2025
11:14
Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection
Published on: November 7, 2018
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Identifying Childhood Risk Factors for Hepatitis B with a Focus on Vertical Transmission
Lorenza Forna1,2, Ancuta Lupu1,2, Laura Bozomitu1,2
1Pediatrics-"Sf. Maria" Clinical Emergency Children's Hospital, Iassy 700309, Romania.
Diseases (Basel, Switzerland)
|September 27, 2024
Summary
Hepatitis B virus (HBV) infection in children is linked to maternal status and birth type. Comprehensive vaccination and monitoring of pregnant women are vital to prevent vertical transmission.
Area of Science:
- Hepatology
- Pediatrics
- Infectious Diseases
Background:
- Hepatitis B virus (HBV) infection persists globally, with significant vertical transmission in endemic areas.
- Romania's history of high childhood HBV rates necessitates ongoing surveillance to assess vaccination impact.
- This study investigates childhood risk factors for HBV, focusing on maternal infection and vertical transmission.
Purpose of the Study:
- To identify childhood risk factors for Hepatitis B virus acquisition.
- To examine the role of maternal HBV status in child HBV infection.
- To evaluate the impact of vaccination programs and identify prevention gaps.
Main Methods:
- A cohort of 654 children was assessed for HBV infection (HBsAg).
- Risk factors and vaccination coverage were analyzed in 148 HBV-positive children.
- Data included birth type, surgical history, and vaccination status.
Main Results:
- 80.4% of 148 HBV-positive children were born naturally; 130 received vaccination.
- Hepatitis B immunoglobulin was administered at birth to 5 children, 4 via cesarean section.
- In a control group of 418 vaccinated children, only 2.2% were unvaccinated.
Conclusions:
- Comprehensive vaccination strategies are essential for preventing childhood HBV infection.
- Birth type and vaccination status show potential correlations with HBV acquisition.
- Vigilant monitoring and treatment of pregnant women with HBV are critical to prevent vertical transmission.
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