Trace Element Concentrations of Arsenic and Selenium in Toenails and Risk of Prostate Cancer among Pesticide Applicators
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View abstract on PubMed
Summary
This summary is machine-generated.This study investigated prostate cancer risk factors, specifically arsenic and selenium levels in toenails. Higher levels of these trace elements were associated with an increased risk of prostate cancer in men.
Area Of Science
- Environmental Health
- Oncology
- Trace Element Analysis
Background
- Prostate cancer is a prevalent malignancy in the United States.
- Risk factors for prostate cancer remain incompletely understood, particularly concerning trace elements.
- Toenail trace element analysis offers a potential method for assessing long-term exposure.
Purpose Of The Study
- To examine the association between prostate cancer and toenail levels of arsenic and selenium.
- To investigate the role of trace elements as potential risk factors for prostate cancer.
Main Methods
- A nested case-control study was conducted within the Agricultural Health Study cohort.
- Toenail samples were collected from prostate cancer cases and controls.
- Neutron activation analysis was used to quantify trace element concentrations, including arsenic.
- Logistic regression models estimated odds ratios for trace element exposure and prostate cancer risk.
Main Results
- Elevated toenail arsenic levels were associated with increased prostate cancer risk (OR = 3.4, 95% CI: 1.3-8.6).
- Higher toenail selenium levels also showed an association with increased prostate cancer risk (OR = 2.0, 95% CI: 1.0-4.0).
- Over 50% of toenail samples showed detectable levels for 14 out of 22 analyzed elements.
Conclusions
- Findings suggest a potential link between toenail arsenic and selenium levels and prostate cancer risk.
- These results support previous ecological studies on arsenic exposure and prostate cancer.
- Further research is warranted to elucidate the role of trace elements in prostate cancer etiology.
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