Formulation and Evaluation of Turmeric- and Neem-Based Topical Nanoemulgel against Microbial Infection

Area of Science:

• Pharmaceutical Sciences
• Nanotechnology
• Dermatology

Background:

• Topical drug delivery systems are crucial for treating localized infections.
• Phytochemicals from turmeric (Curcuma longa) and neem (Azadirachta indica) possess antimicrobial properties.
• Nanoemulsions and nanoemulgels offer enhanced delivery of active compounds.

Purpose of the Study:

• To formulate and characterize a novel nanoemulgel using turmeric and neem extracts for topical antimicrobial delivery.
• To evaluate the physicochemical properties, mucoadhesion, and antimicrobial efficacy of the developed nanoemulgel.
• To assess the stability of the turmeric-neem nanoemulgel for potential therapeutic applications.

Main Methods:

• Nanoemulsions were prepared using olive oil, Tween 80, and PEG600, then gelled with Carbopol 934.
• Characterization included particle size, PDI, FTIR, pH, viscosity, spreadability, and in vitro drug release.
• Antimicrobial activity was tested against various microbial strains, alongside ex vivo mucoadhesion and stability studies.

Main Results:

• The nanoemulsion exhibited small droplet size and low PDI, with FTIR confirming good compatibility.
• The nanoemulgel showed desirable physicochemical properties, including good spreadability and mucoadhesion.
• An 18-hour in vitro drug release was achieved, alongside significant antimicrobial activity and 3-month stability.

Conclusions:

• Turmeric and neem-based nanoemulgel is a stable and effective topical delivery system.
• This formulation demonstrates significant potential for combating microbial infections via topical application.
• The study highlights the synergy of nanotechnology and phytochemistry for advanced drug delivery.